C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61P 25/18 (2006.01) C07D 498/14 (2006.01)
Patent
CA 2723727
The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
La présente invention porte sur des dérivés d'oxazolobenzimidazole qui sont des potentialisateurs de récepteurs métabotropiques du glutamate, en particulier du récepteur mGluR2, et qui sont utiles dans le traitement ou la prévention de troubles neurologiques et psychiatriques associés à un dysfonctionnement du glutamate et aux maladies dans lesquelles des récepteurs métabotropiques du glutamate sont mis en jeu. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur l'utilisation de ces composés et compositions dans la prévention ou le traitement de maladies dans lesquelles les récepteurs métabotropiques du glutamate sont mis en jeu.
Brnardic Edward J.
Converso Antonella
Fraley Mark E.
Garbaccio Robert M.
Huang Shaei Y.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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