Oxazolone derivative

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 263/52 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/10 (2006.01) A61K 31/27 (2006.01) A61K 31/341 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/5375 (2006.01) A61P 19/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2636625

Disclosed is a novel raw material compound which is useful for producing a novel cycloalkanecarboxamide derivative having a cathepsin K inhibitory activity. Specifically disclosed is an oxazolone derivative represented by the following formula (I). (I) (In the formula (I), R1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted phenyl group, a substituted or unsubstituted naphthyl group or a substituted or unsubstituted heterocyclic group; and ring A represents a saturated cyclic alkylidene group having 6-7 carbon atoms.)

La présente invention concerne un nouveau composé de départ qui est utile pour produire un nouveau dérivé cycloalcanecarboxamide ayant une activité d~inhibition de la cathépsine K. La présente invention concerne plus spécifiquement un dérivé oxazolone représenté par la formule (I). (I) (Dans la formule (I), R1 représente un groupe alkyle substitué ou non substitué, un groupe alcényle substitué ou non substitué, un groupe alcynyle substitué ou non substitué, un groupe phényle substitué, un groupe naphtyle substitué ou non substitué ou un groupe hétérocyclique substitué ou non substitué ; et le cycle A représente un groupe alkylidène cyclique saturé ayant de 6 à 7 atomes de carbone.)

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