Oxazolopyridine derivatives as sirtuin modulators

Details Oxazolopyridine derivatives as sirtuin modulators Oxazolopyridine derivatives as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/435 (2006.01) A61P 3/00 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 35/00 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2618370

Provided herein are oxazolopyridine derivatives which are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasingthe lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfêt from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L~invention concerne des dérivés d~oxazolopyridine modulant le sirtuin et leurs méthodes d~utilisation. Les composés modulant le sirtuin peuvent être utilisés pour augmenter la durée de vie d'une cellule, et traiter et/ou empêcher une grande variété de maladies et de troubles y compris, par exemple, des maladies ou troubles en rapport avec le vieillissement ou le stress, le diabète, l~obésité, des maladies neurodégénératives, des maladies cardio-vasculaires, des troubles de la coagulation du sang, l~inflammation, le cancer, et/ou des bouffées vasomotrices ainsi que des maladies ou troubles qui seraient améliorés par une activité mitochondriale augmentée. Elle concerne aussi des compositions qui comprennent un composé modulant le sirtuin en combinaison avec un autre agent thérapeutique.

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