Oxepane isomers of rapamycin useful as immunosuppressive agents

Details Oxepane isomers of rapamycin useful as immunosuppressive agents Oxepane isomers of rapamycin useful as immunosuppressive agents

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/445 (2006.01) A61K 31/70 (2006.01) C07D 471/18 (2006.01) C07D 498/18 (2006.01)

Patent

CA 2086643

A derivative of rapamycin of general formula (I) (see formula I) wherein R1 and R2 are selected from the group consisting of hydrogen, acyl, sulfonyl or alkyl or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.

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