C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/09 (2006.01) C07F 9/141 (2006.01) C07F 9/24 (2006.01) C07F 9/54 (2006.01) C07F 9/6561 (2006.01) C07F 9/6571 (2006.01) C07F 9/6574 (2006.01)
Patent
CA 2233160
A phosphite triester compound which comprises the residue of an ethylenically unsaturated alcohol is oxidised to form the corresponding phosphate triester. The product may be reacted in subsequent steps to form a zwitterionic compound, for instance a phosphoryl choline derivative. In a particularly preferred embodiment of the process, the oxidising agent is a tertiary amine oxide and the starting phosphite triester is a cyclic compound which can be reacted with the amine by-product of the oxidation reaction to open the ring.
Un composé à base de triester de phosphite qui comprend le résidu d'un alcool éthyléniquement insaturé est oxydé pour former le triester de phosphate correspondant. On peut faire réagir le produit dans des étapes subséquentes pour former un composé zwittérionique, par exemple un dérivé de la phosphorylcholine. Dans une application de choix du procédé, l'agent oxydant est un oxyde d'amine tertiaire et le triester de phosphite de départ est un composé cyclique que l'on peut faire réagir avec le sous-produit aminé de la réaction d'oxydation pour ouvrir le noyau.
Browne Judith Elizabeth
Driver Michael John
Biocompatibles Uk Limited
Borden Ladner Gervais Llp
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