Oxidation process using tempo

Details Oxidation process using tempo Oxidation process using tempo

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) C07D 221/04 (2006.01)

Patent

CA 2327931

The present invention relates to an oxidation using sodium chlorite in the presence of a catalytic amount of TEMPO and sodium hypochlorite which converts the penultimate intermediate bearing a primary alcohol to the target endothelin antagonist compound of Formula (I) having a carboxylic acid.

L'invention concerne un procédé d'oxydation au moyen de chlorite de sodium en présence d'une quantité catalytique de TEMPO et d'hypochlorite de sodium, ce qui convertit l'avant-dernier intermédiaire portant un alcool primaire en composé ciblé antagoniste d'endothéline représenté par la formule (I) et possédant un acide carboxylique.

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