Oxidation products of cephalomannine

Details Oxidation products of cephalomannine Oxidation products of cephalomannine

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/337 (2006.01) A61K 31/5355 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2161138

Antineoplastic taxol derivatives are derived by selective oxidation of the alkene portion of the side chain of cephalomannine. The derivative displays high activity in promoting assembly of microtubulin and also displays cytotoxic activity against malignant cells.

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