Oxidation resistant muteins

Details Oxidation resistant muteins Oxidation resistant muteins

C - Chemistry, Metallurgy

12

N

530/13, 167/103.

C12N 15/22 (2006.01) A61K 38/21 (2006.01) C07K 14/55 (2006.01) C07K 14/565 (2006.01)

Patent

CA 1340265

A biologically active reference human therapeutic protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionine residue susceptible to chloramine T or peroxide oxidation, where additional, non-susceptible methionine residues are not so substituted, The oxidation-resistant mutein so produced is preferably a mutein of interleukin-2 or interferon-.beta., and the conservative amino acid is most preferably alanine.

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