Oxidation resistant thrombomodulin analogs

Details Oxidation resistant thrombomodulin analogs Oxidation resistant thrombomodulin analogs

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/49 (2006.01) C07K 14/745 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01) C12N 15/12 (2006.01) C12N 15/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2077691

Novel soluble oxidation resistant thrombomodulin analogs are produced for various therapeutic and other uses, such as in thrombotic and vascular disease therapies. These analogs exhibit the characteristic therapeutic properties of native thrombomodulin, yet they are soluble and are not inactivated after they have been exposed to oxidants. Some of the analogs disclosed are multifunctional fusion proteins having both antithrombotic activity and some additional bioactivity.

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