Oxidation resistant variants of parathyroid hormone

Details Oxidation resistant variants of parathyroid hormone Oxidation resistant variants of parathyroid hormone

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/29 (2006.01) C07K 14/635 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2098283

2098283 9211286 PCTABS00014 Described herein are methionine-substituted variants of parathyroid hormone which, relative to their natural counterparts, exhibit reduced sensitivity to oxidation and substantial PTH activity. Their production using recombinant DNA-based techniques is also described, as is their therapeutic use, e.g. in the treatment of osteoporosis.

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