C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) C07F 9/10 (2006.01) C07F 9/6596 (2006.01) G01N 33/49 (2006.01)
Patent
CA 2654743
The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A = O, C, NH, or S; B = O, C, NH, or S; and R2 is selected from the group consisting of -CO-(CH2)n-CH3; -CO-(CH2)n-CHO; and -CO-(CH2)n-COOH, with n = 3-7, with the proviso that in general formula (I), R1 is selected from the group consisting of -CH2-(CH2)n-X; and -CO-(CH2)n-X with n = 5-11, wherein X is a fluorophore; and in general formula (II), R1 is selected from the group consisting of -CH=CH-(CH2)n-CH3 with n = 9-15; -(CH2)n-CH3 with n = 11-17; and -CO-(CH2)n-CH3 with n - 10-16; and R3 is selected from the group consisting of -CO-(CH2)n-X; and -SO2-(CH2)n-X, with n = 0-5, wherein X is a fluorophore.
L'invention porte sur des phospholipides oxydés présentant l'une des formules générales (I) ou (II) dans lesquelles: A = O, C, NH, ou S; B = O, C, NH, ou S; et R2 est sélectionné parmi -CO-(CH2)n-CH3; -CO-(CH2)n-CHO; et -CO-(CH2)n-COOH, avec n = 3-7, sous réserve que dans la formule générale (I), R1 soit sélectionné parmi -CH2-(CH2)n-X; et -CO-(CH2)n-X avec n = 5-11, X étant un fluorophore. Dans la formule générale (II), R1 est sélectionné parmi -CH=CH-(CH2)n-CH3 avec n = 9-15; -(CH2)n-CH3 avec n = 11-17; et -CO-(CH2)n-CH3 avec n - 10-16; et R3 est sélectionné parmi -CO-(CH2)n-X; et -SO2-(CH2)n-X, avec n = 0-5, X étant un fluorophore.
Hermetter Albin
Trenker Michael
Forschungsholding Tu Graz Gmbh
Sim & Mcburney
Technische Universitaet Graz
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