C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/775 (2006.01) A61K 38/17 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2392355
The present invention relates to oxidized forms of apolipoproteins and methods of use in diagnosis and treatment of diseases associated with oxidative stress, such as cardiovascular diseases, in particular of atherosclerosis. Specifically, oxidized forms of ApoA-1 and ApoA-II having specific methionine residues oxidized are provided. Methods of use include increasing effux and .alpha.-TOH, lowering lipid concentrations and preventing or treating lipid- associated conditions are provided. Methods of detecting oxidative stress, genotypes and extent of lipid associated conditions are also provided by utilizing the oxidative apolipoproteins.
La présente invention porte sur des formes oxydées d'apolipoprotéines et sur leurs procédés d'utilisation dans le diagnostic et le traitement de maladies associées à un stress oxydatif telles que des maladies cardio-vasculaires, notamment l'athérosclérose. L'invention porte notamment sur des formes oxydées d'ApoA-1 et ApoA-II possédant des restes oxydés spécifiques de méthionine. L'invention porte en outre sur des procédés d'utilisation consistant à accroître l'écoulement d'.alpha.-TOH, réduire les teneurs en lipides et prévenir ou traiter des états associés aux lipides ; et sur des procédés de détection du stress oxydatif, des génotypes et de la prolongation des états associés aux lipides au moyen des apolipoprotéines oxydatives.
Stocker Roland
Wang Xing Li
Wilcken David
Blake Cassels & Graydon Llp
The Heart Research Institute Limited
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