Oxidized lipoproteins and methods for their preparation

Details Oxidized lipoproteins and methods for their preparation Oxidized lipoproteins and methods for their preparation

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 38/44 (2006.01) C07K 14/435 (2006.01) C07K 14/775 (2006.01) C12M 1/40 (2006.01)

Patent

CA 2067364

2067364 9105536 PCTABS00005 Methods and apparatuses are disclosed for preparing novel oxidized lipoprotein compositions. Peroxides are capable of generating free-radicals which, in turn, can oxidize lipoproteins in vitro) or in vivo. It has been discovered that hydrogen peroxide itself or in conjunction with certain enzymes such as peroxidase or lipoxidase can oxidize lipoproteins. Peroxidized low density lipoproteins are the most preferred composition. Oxidized lipoproteins exhibit a cytotoxic effect to which diseased cells which are more susceptible than healthy cells. Thus, oxidized lipoproteins may be useful in treating many disease states. The extent of lipoprotein peroxidation is measured by obtaining a C-13 NMR spectrum of the oxidized lipoprotein solution.

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