Oxime and hydroxylamine substituted imidazo[4,5-c] ring...

Details Oxime and hydroxylamine substituted imidazo[4,5-c] ring... Oxime and hydroxylamine substituted imidazo[4,5-c] ring...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/15 (2006.01) A61K 31/437 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2597587

Imidazo[4,5-c] ring compounds, (e.g. imidazo[4,5-c]pyridines, imidazo[4,5- c]quinolines, 6,7,8,9-tetrahydro imidazo[4,5-c]quinolines, imidazo[4,5- c]naphthyridine, and 6,7,8,9-tetrahydro imidazo[4,5-c]naphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Cette invention concerne des composés cycliques imidazo[4,5-c] (tels que des composés imidazo[4,5-c] pyridines, imidazo[4,5-c]quinoléines, 6,7,8,9-tétrahydro imidazo[4,5-c]quinoléines, imidazo[4,5-c]naphtyridine et 6,7,8,9-tétrahydro imidazo[4,5-c]naphtyridine) comprenant un substituant oxime ou hydroxylamine en position 2, des compositions pharmaceutiques contenant ces composés, des intermédiaires, des procédés de production et des procédés d'utilisation de ces composés comme immunomodulateurs pour moduler la biosynthèse de cytokine chez des animaux ainsi que dans le traitement de maladies, telles que des maladies virales et néoplasiques.

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