C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/06 (2006.01) C07C 251/62 (2006.01) C07C 271/60 (2006.01) C07C 323/60 (2006.01) C07C 323/63 (2006.01) C07D 215/14 (2006.01)
Patent
CA 2048518
AHP-9624 OXIME-CARBAMATES AND OXIME-CARBONATES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS Abstract of the Disclosure There are disclosed compounds of the formula Image wherein Image ; R1 is hydrogen, lower alkyl or Image ; a is 1-3; b is 1-3; c is 0-2; X, Y and Z are each, independently, a bond, O, S or NH, with the proviso that if one of X or Y is O, S or NH, the other must be a bond; R2 is amino, loweralkylamino, arylamino, loweralkoxy or aryloxy; R3 is hydrogen, halo, hydroxy, lower alkoxy, aryloxy, loweralkanoyloxy, amino, lower alkylamino, arylamino or loweralkanoylamino; R4 and R5 are each, independently hydrogen or lower alkyl; m is 0-4; n is 1-4; and o is 1-4; and, which by virtue of their ability to selectively inhibit an isoenzyme of 3':5'-cyclic AMP phosphodiesterase located in pulmonary smooth muscle tissue and inflammatorycells, are bronchodilatory and antiinflammatory and so are useful in the treatment of acute and chronic bronchial asthma and associated pathologies.
American Home Products Corporation
Ridout & Maybee Llp
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