Oxime derivative

Details Oxime derivative Oxime derivative

C - Chemistry, Metallurgy

07

D

C07D 213/55 (2006.01) A61K 31/195 (2006.01) A61K 31/395 (2006.01) C07C 239/20 (2006.01) C07C 251/54 (2006.01) C07C 251/60 (2006.01) C07D 205/10 (2006.01) C07D 207/337 (2006.01) C07D 213/53 (2006.01) C07D 223/04 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2100918

An oxime derivative (1): Image (I) wherein R' is hydrogen or lower alkyl; R2 is hydrogen, alkyl, phenyl, cycloalkyl, a monocyclic ring containing nitrogen, lower alkyl substituted by a benzene ring or cycloalkyl, or a lower alkyl substituted by a monocyclic ring containing nitrogen; R3 is alkyl, phenyl, cycloalkyl, a monocyclic ring containing nitrogen, a lower alkyl substituted by a benzene ring or cycloalkyl, or lower alkyl substituted by a monocyclic ring containing nitrogen, wherein the ring in R2 and R3 may be substituted by lower alkyl, alkoxy, halogen, nitro, or trihalomethyl; and salts thereof. These compounds possess PGI2 receptor agonist activity, and are expected to be useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension. -36-

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