Oxime derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2082334

ABSTRACT An oxime derivative of the formula: Image (I) wherein R is a hydrogen atom or a C1-5 alkyl group, R1 is a hydrogen atom, a C1-5 alkyl group or a carboxyl- protecting group, R2 is a hydrogen atom, a halogen atom, a hydroxyl group or an amino group, R3 is a C3-7 cycloalkyl group, R4 is a hydrogen atom, a halogen atom or a C1-4 alkoxy group, each of R5 and R6 which may be the same or different, is a hydrogen atom or a C1-5 alkyl group, or R5 and R6 together represent a C2-4 alkylene group which forms together with the adjacent carbon atom a C3-5 ring, provided that when R2 is a hydrogen atom, R4 is a C1-4 alkoxy group, m is an integer of 0 or 1, and n is an integer of from 1 to 3; or its salt.

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