Oxime derivatives

Details Oxime derivatives Oxime derivatives

C - Chemistry, Metallurgy

07

D

C07D 309/12 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/70 (2006.01) C07D 307/20 (2006.01) C07D 309/10 (2006.01) C07D 317/22 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 407/02 (2006.01) C07D 409/02 (2006.01) C07D 409/04 (2006.01) C07D 417/00 (2006.01) C07D 417/04 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2088864

A B S T R A C T OXIME DERIVATIVES The invention concerns oxime derivatives of the formula I Image I wherein R4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and (1-4C)alkyl; R5 includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, (2-5C)alkanoyl, halogeno-(2-4C)alkyl and hydroxy-(2-4C)alkyl; Ar1 is phenylene or a heteroaryl diradical; A1 is a direct link to X1, or A1 is (1-4C)alkylene; X1 is oxy, thio, sulphinyl or sulphonyl; Ar2 is phenylene or a heteroaryl diradical; R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R2 and R3 together form a group of the formula -A2-X2-A3- which together with the carbon atom to which A2 and A3 are attached define a ring having 5 or 6 ring atoms, wherein each of A2 and A3 is (1-3C)alkylene and X2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

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