Oxime derivatives, their preparation and their therapeutic use

Details Oxime derivatives, their preparation and their therapeutic use Oxime derivatives, their preparation and their therapeutic use

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) C07D 263/44 (2006.01) C07D 271/07 (2006.01) C07D 277/34 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2159938

Compounds of formula (I): Image (I) wherein: R1 is hydrogen or alkyl; R2 is alkylene; R3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino, aryl, or aralkyl; X is aryl, or aromatic heterocyclic; Y is oxygen, sulfur or a group of formula >N-R4, in which R4 is hydrogen, alkyl or acyl; and Z is a group of formula (Za, (Zb), (Zc) or (Zd): Image Image (Za) (Zb) Image Image (Zc) (Zd) and salts thereof can be used to treat or prevent are included those arising from hyperlipidemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistant non-IGT (NGT), non-diagnostic glucose tolerance, insulin resistance, diabetic complications, fatty liver, polycystic ovary sydrome (PCOS) and gestational diabetes mellitus (GDM); in addition the compounds of the present invention have aldose reductase inhibitory activity.

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