Oxime ethers and process for the preparation thereof

Details Oxime ethers and process for the preparation thereof Oxime ethers and process for the preparation thereof

C - Chemistry, Metallurgy

07

D

260/247.7, 260/5

C07D 295/12 (2006.01) C07D 295/088 (2006.01)

Patent

CA 1071201

Abstract Novel oxime others of formula I Image /I/ and their optical isomers, salts and quaternary ammonium derivatives, wherein R stands for a phenyl group which may be substituted by a halogen atom or by one or more C1-C4 alkoxy, hydroxyl, nitro or di/C1-C3 alkyl/amino groups; R1 and R2 denote each a hydrogen atom or together a valence bond; A denotes a C2-C4 straight or branched-chain alkylene group; B denotes an amino or a di/C1-4 alkyl/-amino group or a group of general formula VII Image /VII/ wherein R3 and R4 denote together a C4-C7 alkylene chain which may contain also a further oxygen or nitrogen heteroatom and the latter may carry also a C1-C3 alkyl or a benzyl substituent; and n denotes an integer from 3 to 10. The new compounds according to the invention possess valuable therapeutic effects. Thus they show local analgesic, spasmolytic, nicotine-lethality inhibiting, tetrabenazine- -antagonistic and tetracer-spasm inhibiting effects.

245043

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