Oxime ethers having anti-depressive activity

Details Oxime ethers having anti-depressive activity Oxime ethers having anti-depressive activity

A - Human Necessities

61

K

260/559.4, 260/5

A61K 31/275 (2006.01) A61K 31/15 (2006.01)

Patent

CA 1077519

ABSTRACT Image I wherein R is the group (CH2)pCN, the group (CH2)qCH3, or the group (CH2)r o(CH2)2 OCH3 wherein p is 1, 2 or 3, q is 1 when p is 1, while q is zero when p is 2 or 3, and r is o, 1 or 2, and their salts prove to have a strong anti- depressive activity. This is expressed in a strong potentiation of noradrenaline and in a strong serotonin potentiation. Mono- amino oxidase inhibition provides no contribution to the anti-depressive activity. The compounds are free from noxious side effects to a considerable extent, for example bronchoconstriction and stomach ulceratrion. The novel compounds can be prepared and formulated to compositions by means of methods known per se.

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