C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/592, 260/267
C07D 295/12 (2006.01) C07D 295/088 (2006.01)
Patent
CA 1146170
ABSTRACT OF THE DISCLOSURE The invention relates to novel oxime ethers of the general formula (I)and acid addition salts and quaternary ammonium derivatives thereof, Image (I) wherein A represents a C2-6 straight or branched alkylene chair, R and R1 each represent a C1-6 alkyl group or they form together with the adjac-ent nitrogen atom a piperazinyl ring optionally substantially by a C1-3 alkyl, phe- nyl or benzyl group, R2 and R3 each denote a hydrogen atom or together form a valency bond, R4 denotes a C1-10 alkyl or C2-10 alkenyl group, and n denotes the integer 4 or 5. The compounds of the general formula (I) are pre-pared according to the invention by reacting a cycloalkene derivatibe of the general formula: - 2 - Image /II/ wherein R2, R3, R4 and n have the same meaning as above, whereas Y denotes an oxygen or sulphur atom or a = N - OH group with an aminoalkyl derivative of the general formula /III/ Image /III/ wherein R, R1 and A have the same meaning as stated above and % means a halogen atom or a H2N - O - group or a salt there- of in the presence of a basic condensing agent. The new compounds of the general formula /1/ possess valuable nicotine-lethality inhibiting, local anaesthetic, analgesic effects, which are, in case of certain compounds, complemented by anti-hypertensive, maximum electroshock and tetracorspasm inhibiting, ulcus inhibiting and motility inhibiting effects, and can be applied to advantage in the therapy.
355280
(nee Kiszelly) Szirt Eniko
(nee Konya) Lay Aranka
Budai Zoltan
Gorog Peter
Grasser Katalin
Egyt Gyogyszervegyeszeti Gyar
Fetherstonhaugh & Co.
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