Oxindole derivative

Details Oxindole derivative Oxindole derivative

C - Chemistry, Metallurgy

07

D

167/231, 167/240

C07D 209/34 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2037923

The present invention provides an oxindole derivative derivative which has the following formula and is useful for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives: (1) Image wherein: R1 represents a group selected from H, a halogen atom, lower alkyl and lower alkoxyl; R2 represents a group selected from H and lower alkyl: R3 represents -CH2-R5, wherein R5 represents a group selected from lower alkyl, C3-6 cycloalkyl, pyridyl, benzodioxanyl, phenyl and phenyl substituted by from one to 3 groups selected from a halogen atom, -OH, -CN, -NO2, -CF3, -N(C2H5)2, lower alkyl, lower alkoxyl and benzyloxy; or R2 and R3 together represent =CH- R5, wherein R5 is as defined above; and R4 represents a group selected from 1-propylbutyl, pyridyl, phenyl and phenyl substituted by at least one substituent selected from a halogen atom, -CN, -NO2, -CF3, -N(C2H5)2, lower alkyl, lower alkoxyl and benzyloxy.

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