Oxindole derivatives

Details Oxindole derivatives Oxindole derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2612451

The invention describes compounds of the general formula (I-A) or the pharmaceutically acceptable salts thereof, wherein R1, R2, R4 and R5 are herein described, a process for their manufacture, medicaments containing them as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as antiproliferative agents and may be especially useful for the treatment of cancer.

L'invention concerne des composés représentés par la formule générale (I-A) ou des sels pharmaceutiquement acceptables de ceux-ci. Dans cette formule, R1, R2, R4 et R5 sont tels que définis dans le descriptif. L'invention concerne également un procédé de fabrication de ces composés, des médicaments les contenant ainsi que l'utilisation de ces composés en tant qu'agents pharmaceutiquement actifs. Ces composés font preuve d'une activité en tant qu'agents antiproliférants et peuvent être utilisés plus spécifiquement pour le traitement du cancer.

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