Oxindole derivatives as growth hormone releasers

Details Oxindole derivatives as growth hormone releasers Oxindole derivatives as growth hormone releasers

C - Chemistry, Metallurgy

07

D

C07D 209/38 (2006.01) A61K 31/40 (2006.01) C07D 209/40 (2006.01) C07D 401/04 (2006.01) C07D 403/06 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2340701

An oxindole of Formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser wherein R1, R2, R3, and R4 are independently hydrogen, optionally substituted alkyl, etc; R5 is optionally substituted aryl or optionally substituted heteroaryl; Z is -O- or -NH-; one of W1 and W2 is hydrogen, alkyl or -Y-CON(R10)R11; the other of W1 and W2 is (a); n is 1, 2 or 3; m is 0, 1, 2 or 3; Y is single bond or C1-C3 alkylene; R6 and R7 are independently hydrogen, optionally substituted alkyl, etc; R8 and R9 are independently hydrogen, optionally substituted alkyl, etc; R10 and R11 are independently hydrogen, alkyl etc.

L'invention concerne un oxindole correspondant à la formule (1), ou un promédicament, ou un sel pharmaco-acceptable, de ce dérivé, et utile en tant qu'agent de libération de l'hormone de croissance. Dans cette formule, R<1>, R<2>, R<3> et R<4> représentent indépendamment hydrogène, alkyle éventuellement substitué, etc., R<5> représente aryle ou hétéroaryle, éventuellement substitués, Z représente -O- ou -NH-, l'un des W<1> et W<2> représente hydrogène, alkyle ou -Y-CON(R<10>)R<11>, l'autre correspondant à la formule (a) dans laquelle n vaut 1, 2 ou 3, m vaut 0, 1, 2 ou 3, Y représente une liaison simple ou alkylène C1-C3, R<6> et R<7> représentent indépendamment hydrogène, alkyle éventuellement substitué, etc., R<8> et R<9> représentent indépendamment hydrogène, alkyle éventuellement substitué, etc., R<10> et R<11> représentent indépendamment hydrogène, alkyle, etc..

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