Oxindoledioxans, synthesis thereof, and intermediates thereto

Details Oxindoledioxans, synthesis thereof, and intermediates thereto Oxindoledioxans, synthesis thereof, and intermediates thereto

C - Chemistry, Metallurgy

07

D

C07D 319/20 (2006.01)

Patent

CA 2652800

The present invention provides methods for preparing a compound of formula D having activity as dopamine autoreceptor agonist and partial agonists at the postsynaptic dopamine D2 receptor. This compound is useful for treating dopaminergic disorders, such as schizophrenia, schizoaffective disorder, Parkinson's disease, Tourette's syndrome, hyperprolactinemia and drug addiction. (Formula I).

La présente invention concerne des procédés destinés à la préparation de composés dotés d'une activité d'agonistes auto-récepteurs et d'agonistes partiels de la dopamine au niveau du récepteur postsynaptique D<SUB>2</SUB> de la dopamine. Ces composés se révèlent utiles pour le traitement de troubles dopaminergiques, tels que la schizophrénie, le trouble schizo-affectif, la maladie de Parkinson, le syndrome de Tourette, l'hyperprolactinémie, et la toxicomanie.

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