Oxo-analogs of mevinolin-like antihypercholesterolemic agents

Details Oxo-analogs of mevinolin-like antihypercholesterolemic agents Oxo-analogs of mevinolin-like antihypercholesterolemic agents

C - Chemistry, Metallurgy

07

C

167/262, 260/477

C07C 59/84 (2006.01) A61K 31/215 (2006.01) C07C 33/46 (2006.01) C07C 59/90 (2006.01) C07C 69/738 (2006.01) C07C 205/09 (2006.01) C07D 261/08 (2006.01)

Patent

CA 1327360

TITLE OF THE INVENTION OXO-ANALOGS OF MEVINOLIN-LIKE ANTIHYPER- CHOLESTEROLEMIC AGENTS ABSTRACT OF THE INVENTION Mevinolin-like compounds in which the lactone is opened and the hydroxyl function produced thereby is replaced by an oxo function are potent HMG-CoA reductase inhibitors possessing one less asymmetric center.

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