Oxopiperidine derivatives, preparation and therapeutic use...

Details Oxopiperidine derivatives, preparation and therapeutic use... Oxopiperidine derivatives, preparation and therapeutic use...

C - Chemistry, Metallurgy

07

D

C07D 295/108 (2006.01) A61K 31/445 (2006.01) A61P 15/00 (2006.01) C07D 451/04 (2006.01)

Patent

CA 2577177

The invention concerns oxopiperidine derivatives of general formula (I) wherein: n = 1; Ra, Ra.prime., Rb et Rb.prime. represent hydrogen atoms or alkyl or cycloalkyl groups, or Rb and Rb.prime. together form a carbon bridge; R1 represents an alkyl or cycloalkyl group; R2 represents a heteroaryl group; R3 represents 1 to 3 groups selected among halogen atoms and alkyl, cycloalkyl, -OR, -NRR', -CO-NRR', -NR-CO-R', -NR-CO-NRR1, -NR-COOR', -NO2, -CN and COOR groups; R5 represents a hydrogen atom or an alkyl group; R4 is selected among the groups of formulae (a), (b) and (c), wherein p = 0, 1, 2 or 3, m = 0, 1 or 2, and X represents a -C(R6)(R7)- or -N(R10)- member. The invention also concerns a method for preparing said derivatives and their therapeutic use.

L'invention concerne des dérivés d'oxopipéridine de formule générale (I) dans laquelle : n est égal à 1 , Ra, Ra.prime., Rb et Rb.prime. représentent des atomes d'hydrogène ou des groupes alkyles ou cycloalkyles, ou Rb et Rb.prime. forment ensemble un pont carboné, R1 représente un groupe alkyle ou cycloalkyle, R2 représente un groupe hétéroaryle, R3 représente 1 à 3 groupes choisis parmi les atomes d'halogène et les groupes alkyles, cycloalkyles, -OR, -NRR.prime., -CO-NRR.prime., -NR-CO-R.prime., -NR-CO-NRR.prime., -NR- COOR.prime., -NO2, -CN et -COOR, R5 représente un atome d'hydrogène ou un groupe alkyle, R4 est choisi parmi les groupes de formules (a), (b) et (c), dans lesquelles p = 0, 1 , 2 ou 3, m = 0, 1 ou 2, et X représente un chaînon - C(R6)(R7)- ou -N(R10)- : (a) (b) (c). Procédé de préparation et application en thérapeutique.

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