Oxopyridinylquinoxaline derivative

Details Oxopyridinylquinoxaline derivative Oxopyridinylquinoxaline derivative

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2146478

An oxopyridinylquinoxaline derivative represented by the following Formula I or pharmaceutically acceptable salts thereof: Image (I) wherein R1 is hydrogen, halogen, nitro, or trihalomethyl; R2 is hydrogen, halogen, nitro, cyano, trihalomethyl, carbamoyl, carbamoyl substituted with lower alkyl, sulfamoyl, or sulfamoyl substituted with lower alkyl; R3 is hydrogen, nitro, or halogen; R4 is hydrogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, or substituted lower cycloalkyl; R5's are substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, carbamoyl, and carbamoyl substituted with lower alkyl; and n is an integer of 0 to 4. The derivative works as an antagonis- tic agent against both the NMDA receptors and the AMPA receptors, so that it is effective as a therapeutic agent for neurological disorders caused by excitatory amino acids binding to the receptors.

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