Oxyalkylene phosphate compounds and uses thereof

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 9/40 (2006.01) A61K 31/66 (2006.01) C07F 9/09 (2006.01) C07F 9/113 (2006.01) C07F 9/165 (2006.01) C07F 9/58 (2006.01)

Patent

CA 2283162

This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, modulating gene expression and in particular, augmenting expression of tumor suppressor genes, inducing tolerance to antigens, treating, preventing or ameliorating protozoan infection, or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use oxyalkalene phosphate compounds.

L'invention concerne des compositions et des procédés de traitement, de prévention et de lutte contre le cancer et d'autres maladies prolifératives, ainsi que des procédés qui favorisent la cicatrisation, traitent les ulcérations cutanées, les troubles gastro-intestinaux, et les dysfonctionnements sanguins tels que l'anémie. Ces procédés favorisent également l'immunomodulation et l'expression génique recombinée, traitent les patients insulinodépendants et les patients souffrant de mucoviscidose, inhibent l'activité télomérase, traitent les tumeurs virales, notamment les tumeurs liées au virus Epstein-Barr, modulent l'expression génique, et en particulier augmentent l'expression de gènes suppresseurs de tumeur, encouragent la tolérance aux antigènes, traitent, préviennent ou luttent contre les protozooses, ou inhibent l'histone déacétylase cellulaire. Les compositions et les procédés de cette invention utilisent des composés d'oxyalkylène phosphate.

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