Oxygen analogs of cephalosporins

Details Oxygen analogs of cephalosporins Oxygen analogs of cephalosporins

C - Chemistry, Metallurgy

07

D

260/108.5

C07D 501/00 (2006.01)

Patent

CA 1150241

ABSTRACT OF THE DISCLOSURE The present invention provides oxygen analogs of cephal- sporins having the formula Image where R' is an organic nucleophile selected from hydrogen, halo- gen, hydroxy, alkoxy, aryloxy, alkaryloxy, alkylamino, arylamino, carboxyl, aminocarboxyl, alkylaminocarboxyl, organocarboxyl, organosulfonyl, carbanyl, thiocarboxyl, alkylthiocarboxyl, aryl- thiocarboxyl, alkylthiodiazylthio, the radical Image or the radical Image , R'' is hydrogen or a pharmaceutically accept- able blocking group and R''' is an organic electrophile selected from the organocarbonyl groups, organothiocarbonyl groups, organo- ether groups and organosulphonyl groups. The compounds are bio- logically active.

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