C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 17/00 (2006.01) C07K 14/805 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2266744
Described are preferred oxygen-binding heme proteins which include at least one hemoglobin molecule incorporating at least one circularly permuted globin, especially an alpha globin. More preferred heme proteins of the invention include high molecular weight hemoglobin multimers. Also described are polynucleotides encoding proteins of the invention, and vectors and host cells including the same.
L'invention concerne des protéines d'hèmes de liaison d'oxygène voulues qui comprennent au moins une molécule d'hémoglobine contenant au moins une globine à permutation circulaire, notamment une alpha globine. Selon l'invention, des protéines d'hèmes idéales comprennent des multimères d'hémoglobine de poids moléculaire élevé. L'invention concerne également des polynucléotides codant des protéines de l'invention, ainsi que des vecteurs et des cellules hôtes comprenant ces protéines.
Sanders Kevin
Sligar Stephen G.
Smart & Biggar
The Board Of Trustees Of The University Of Illinois
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