Oxygen linked pyrimidine derivatives

Details Oxygen linked pyrimidine derivatives Oxygen linked pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 498/02 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07D 495/12 (2006.01) C07D 498/12 (2006.01)

Patent

CA 2629443

The present invention relates to pyrimidine compounds that are useful as anti- proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.

L'invention concerne des composés de pyrimidine utiles comme agents antiprolifératifs. Plus particulièrement, l'invention concerne des composés de pyrimidine à liaison oxygène et substitués, des procédés de préparation, des compositions pharmaceutiques contenant ces composés et l'utilisation de ceux-ci dans le traitement de troubles prolifératifs. Ces composés, utilisés comme médicaments, sont destinés à traiter des troubles prolifératifs tels que des tumeurs et des cancers ainsi que d'autres troubles ou états pathologiques liés ou associés aux kinases.

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