C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/04 (2006.01) A61K 31/33 (2006.01) C07D 307/20 (2006.01) C07D 309/12 (2006.01) C07D 317/24 (2006.01) C07D 319/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/00 (2006.01) C07D 409/00 (2006.01) C07D 411/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)
Patent
CA 2217745
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV- 1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention.
La présente invention se rapporte à une nouvelle classe de sulfamides qui sont des inhibiteurs de l'aspartyle protéase, ainsi qu'à des compositions pharmaceutiques comprenant ces composés. Les composés et les compositions pharmaceutiques de cette invention sont notamment appropriés pour inhiber l'activité des protéases du VIH1 et du VIH2, et, par conséquent, peuvent être utilisés, pour plus d'efficacité, comme agents antiviraux contre le VIH1 et le VIH2. Cette invention se rapporte également à des procédés d'inhibition de l'activité de l'aspartyle protéase du VIH qui mettent en oeuvre ces composés.
Bhisetti Govinda Rao
Tung Roger D.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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