Oxyimino derivatives of thiazole, method of preparation and...

Details Oxyimino derivatives of thiazole, method of preparation and... Oxyimino derivatives of thiazole, method of preparation and...

C - Chemistry, Metallurgy

07

D

167/208, 260/302

C07D 277/20 (2006.01) A61K 31/425 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1324132

ABSTRACT OF THE DISCLOSURE The present invention relates to novel oxyimino derivatives of thiazole consisting of the E and z diastereoisomers of the formula: Image (I) in which R1 represents H, F, Cl, Br, CF3 or CH3 and R2 represents a C1-C10-alkyl group, a benzyl group of the formula CH2C6H2(R3)3, in which each R3 identical or different represents H, F, Cl, Br, CF3, a C1-C4- alkyl group or a C1-C4-alkoxy group, a group CH2COOR4, in which R4 represents H, a C1-C4-alkyl group or the ammonium group, NH4+, a group CH2COOM, m m in which M is an alkali metal or alkaline earth metal and m is its valency, or a 2-aminoethyl group of the formula CH2CH2NR5R6, in which R5 and R6, which can be identical or different, each represents H or a C1-C4-alkyl group, or R5 and R6, taken together with the nitrogen atom to which they are bonded, form a 5- to 7-membered N-heterocyclic group which may contain a second heteroatom selected from N, O and S and may be substituted, or R2 represents a hydrogen atom when R1 is other than H, and the addition salts of the said E and Z isomers. These novel derivatives, as well as the compound of formula (I) in which R1=R2=H, are useful in therapy as anticonvulsants.

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