Oxyindole derivatives as 5ht4 receptor agonists

Details Oxyindole derivatives as 5ht4 receptor agonists Oxyindole derivatives as 5ht4 receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/454 (2006.01) A61P 1/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2598536

This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, R1 , R2, R3 , R4 and R5 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonisitic activity such as, but not limited to, as gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes or apnea syndrome.

L'invention concerne des composés de formule (I) ou un de leurs sels pharmaceutiquement acceptables où : A, R1, R2, R3, R4 et R5 sont décrits dans la description, ou un sel pharmaceutiquement acceptable, et des compositions contenant ces composés ainsi que leur utilisation dans le traitement d'un état à médiation par une activité de récepteur 5-HT4 tel que (mais de façon non restrictive) le reflux oeso-gastrique, la maladie gastro-intestinale, le trouble de motilité gastrique, la dyspepsie non ulcéreuse, la dyspepsie fonctionnelle, le syndrome du côlon irritable (IBS), la constipation, la dyspepsie, l'oesophagite, la maladie oeso-gastrique, la nausée, la maladie du système nerveux central, la maladie d'Alzheimer, le trouble cognitif, le vomissement, la migraine, le trouble neurologique, la douleur, les troubles cardiovasculaires, l'insuffisance cardiaque, l'arythmie, le diabète et le syndrome d'apnée

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