Oxyntomodulin analogues and their effects on feeding behaviour

Details Oxyntomodulin analogues and their effects on feeding behaviour Oxyntomodulin analogues and their effects on feeding behaviour

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) A61K 38/26 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2612063

Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15 - 24 of oxm to either amino acids 968 - 977 of the .alpha.-latrotoxin peptide (and variations thereof) or amino acids 15 -24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27 - 33 of oxm to amino acids 27 - 33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake.

L'invention concerne des composés qui sont de nouveaux analogues peptidiques de l'oxyntomoduline (oxm), dans lesquels un ou plusieurs acides aminés de la séquence oxm a/ont été remplacé(s). Le remplacement des acides aminés 15 - 24 de oxm par les acides aminés 968 - 977 du peptide de l'a-latrotoxine (et des variations de celui-ci) ou par les acides aminés 15 -24 de l'exendine 4 (et des variations de celle-ci), ou par des combinaisons de séquences provenant de ces sources, et/ou le remplacement des acides aminés 27 - 33 de oxm par les acides aminés 27 - 33 de l'exendine 4 et/ou l'addition d'acides aminés à la terminaison C du peptide, permet(tent) d'obtenir une série d'analogues d'oxm présentant une activité du type oxm entraînant une réduction de la prise alimentaire. Dans certaines formes de réalisation, ces composés possèdent une capacité supérieure à réduire la prise alimentaire.

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