Ozonation products of cholesterol for the treatment and...

Details Ozonation products of cholesterol for the treatment and... Ozonation products of cholesterol for the treatment and...

C - Chemistry, Metallurgy

07

J

C07J 9/00 (2006.01) A61K 31/56 (2006.01) A61K 31/575 (2006.01) A61K 39/385 (2006.01) A61K 39/44 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) C07C 49/403 (2006.01) C07C 49/507 (2006.01) C07C 49/633 (2006.01) C07D 313/04 (2006.01) C07J 61/00 (2006.01)

Patent

CA 2537976

As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cytotoxic cholesterol oxidation or ozonation products. The present application is directed to the products of cholesterol ozonation, binding entities directed against such products, and methods of using such binding entities and cytotoxins to treat a variety of diseases.

Comme décrit dans l'exposé le cholestérol est oxydé lorsqu'il est en présence de plaques d'athérosclérose. Cette réaction génère des produits d'oxydation ou d'ozonisation de cholestérol cytotoxiques. La présente invention a trait à des produits d'ozonisation de cholestérol, des entités de liaison dirigées contre de tels produits, et des procédés d'utilisation de telles entités de liaison et de cytotoxines pour traiter une variété de maladies.

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