P-38 inhibitors

Details P-38 inhibitors P-38 inhibitors

A - Human Necessities

61

K

A61K 31/426 (2006.01) A61P 29/00 (2006.01) C07D 249/14 (2006.01) C07D 263/48 (2006.01) C07D 271/06 (2006.01) C07D 277/38 (2006.01) C07D 277/42 (2006.01) C07D 277/56 (2006.01) C07D 285/08 (2006.01) C07D 285/12 (2006.01) C07D 417/04 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2528438

Provided are aminoaryl substituted 5-membered heterocycle-based p38 kinase, including p38alfa and p38beta. Pharmaceutical compositions containing the compounds are also provided. Method of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

L'invention concerne des p38 kinase hétérocycliques à 5 chaînons, y compris des inhibiteurs de la p38 kinase, de la p38 alpha-kinase et de la p38 bêta-kinase. Elle concerne également des compositions pharmaceutiques contenant ces composés; et des méthodes d'utilisation des composés et des compositions de l'invention, notamment de méthodes de traitement, de prévention ou d'amélioration d'un ou de plusieurs symptômes de maladies ou de troubles induits par la p38 kinase, tels que, mais pas exclusivement, les maladies ou troubles inflammatoires.

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