C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/104 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C12N 15/13 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2525291
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
L'invention concerne des peptides, et particulièrement des anticorps monoclonaux humains, qui se lient spécifiquement à l'exopolysaccharide mucoïde de P. aeruginosa. Par ailleurs l'invention concerne des procédés d'utilisation de ces peptides dans le diagnostic, la prophylaxie et la thérapie de l'infection par P. aeruginos ainsi que des troubles connexes (par exemple, la mucoviscidose). Certains modes de réalisation de l'invention améliorent la suppression par opsonophagocytose de souches mucoïdes multiples de P. aeruginosa. L'invention concerne également des compositions qui renferment ces peptides, y compris des compositions pharmaceutiques, ainsi que des variants équivalents sur le plan fonctionnel, tels que les peptides.
Cavacini Lisa
Pier Gerald B.
Posner Marshall
Preston Michael J.
Beth Israel Deaconess Medical Center Inc.
Brigham And Women's Hospital Inc.
Smart & Biggar
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