P-boronophenylalanine complexes with fructose and related...

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 1/00 (2006.01) A61K 31/69 (2006.01) A61K 31/70 (2006.01) C07B 59/00 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2368634

The present invention is directed to salt-free and essentially salt-free p- boronophenylalanine-carbohydrate or p-boronophenylalanine-polyol complexes, as well as methods for making such compounds. In addition, the present invention provides methods for substantially solubilizing freeze-dried p- boronophenylalanine-carbohydrate and p-boronophenylalanine-polyol complexes. The present invention further provides compositions and methods for enhancing the solubility of boronophenylalanine.

L'invention concerne des complexes p-boronophénylalanine-glucide ou p-boronophénylalanine-polyol déchlorurés et sensiblement déchlorurés, ainsi que des méthodes de fabrication de ces composés. L'invention concerne également des méthodes permettant de solubiliser sensiblement des complexes p-boronophénylalanine-glucide et p-boronophénylalanine-polyol lyophilisés. L'invention concerne enfin des compositions et des méthodes permettant d'améliorer la solubilité de la boronophénylalanine.

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