P-cadherin antibodies

Details P-cadherin antibodies P-cadherin antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2604357

The present invention relates to antibodies including human antibodies and antigen- binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P- cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

La présente invention concerne des anticorps, y compris des anticorps humains et leurs fragments de liaison à l'antigène, qui se lient à la P-cadhérine et fonctionnent pour inhiber la P-cadhérine. L'invention concerne également des immunoglobulines à chaîne lourde ou à chaîne légère dérivées d'anticorps humains de la P-cadhérine, et des molécules d'acides nucléiques codant ces immunoglobulines. L'invention concerne aussi des méthodes de production d'anticorps de la P-cadhérine, des compositions comprenant ces anticorps, et des méthodes d'utilisation desdits anticorps et compositions. L'invention concerne en outre des animaux ou des plantes transgéniques comprenant des molécules d'acides nucléiques de l'invention.

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