P-cadherin as a target for anti-cancer therapy

Details P-cadherin as a target for anti-cancer therapy P-cadherin as a target for anti-cancer therapy

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 16/28 (2006.01) C12N 5/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2445611

Method of treating or diagnosing cancers involving P-cadherin expression are provided using ligands that target P-cadherin, especially human anti-P- cadherin antibodies. Also provided are screens for identifying anti-P-cadherin antibodies having therapeutic activity.

Cette invention se rapporte à un procédé pour traiter ou diagnostiquer des cancers impliquant l'expression de P-cadhérine, en utilisant des ligands qui ciblent la P-cadhérine, en particulier des anticorps anti-P-cadhérine humains. Cette invention concerne également des criblages pour identifier des anticorps anti-P-cadhérine ayant une action thérapeutique.

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