C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2384981
The invention pertains to dog P-glycoproteins and related P-glycoproteins which include dog-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the dog P-glycoprotein. The invention further relates to methods of using such dog P-glycoprotein nucleic acids and polypeptides, especially in methods for determining bioavailability of drugs and for sreening for inhibitors of dog PGP. Also included are dog PGP inhibitors which inhibit dog PGP activity by inhibiting the expression or function of dog PGP.
La présente invention concerne des glycoprotéines P canines et les glycoprotéines P associées comprenant des acides aminés spécifiques du chien, ainsi que les acides nucléiques codant lesdits polypeptides. La présente invention concerne également des fragments et des variants biologiquement fonctionnels de la glycoprotéine P du chien. L'invention concerne, en outre, des méthodes d'utilisation des acides nucléiques et des polypeptides de la glycoprotéine P du chien, notamment dans le cadre de techniques visant à déterminer la biodisponibilité de médicaments et à cribler des inhibiteurs de la glycoprotéine P du chien. L'invention concerne enfin des inhibiteurs de la glycoprotéine P du chien qui inhibent l'activité de ladite glycoprotéine par inhibition de l'expression ou de la fonction de la glycoprotéine P du chien.
Crespi Charles L.
Patten Christopher J.
Reif Timothy C.
Steimel-Crespi Dorothy T.
Stocker Penny J.
Gentest Corporation
Smart & Biggar
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