P-glycoproteins from macaca fascicularis and uses thereof

Details P-glycoproteins from macaca fascicularis and uses thereof P-glycoproteins from macaca fascicularis and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2386029

The invention pertains to cynomologous monkey P-glycoproteins and related P- glycoproteins which include cynomologous-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the cynomologous monkey P-glycoprotein. The invention further relates to methods of using such cynomologous monkey P-glycoprotein nucleic acids and polypeptides, especially in methods for determining bioavailability of drugs and for screening for inhibitors of cynomologous PGP. Also included are cynomologous PGP inhibitors which inhibit cynomologous PGP activity by inhibiting the expression or function of cynomologous PGP.

L'invention concerne des P-glycoprotéines de singe cynomolgus et des P-glycoprotéines associées qui comprennent des acides aminés spécifiques dudit singe cynomolgus, ainsi que des acides nucléiques qui codent ces polypeptides. La présente invention a également trait à des fragments et des variants biologiquement fonctionnels de la P-glycoprotéine du singe cynomolgus, ainsi qu'à des méthodes d'utilisation de tels polypeptides et acides nucléiques de ladite P-glycoprotéine, notamment des méthodes de détermination de la biodisponibilité de médicaments et de criblage d'inhibiteurs de ladite P-glycoprotéine. Cette invention concerne aussi des inhibiteurs de ladite P-glycoprotéine qui inhibent l'activité de celle-ci par inhibition de l'expression ou de la fonction de ladite P-glycoprotéine.

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