P-selectin ligand proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2263889

A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO 2 or by the amino acid sequence set forth in SEQ ID NO 4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

Nouvelle glycoprotéine ligand de P-sélectine, qui comporte la séquence d'acides aminés présentée dans SEQ ID NO:2 ou par la séquence d'acides aminés présentée dans SEQ ID NO:4. Des séquences d'ADN codant la protéine ligand de P-sélectine sont également décrites, ainsi que des vecteurs, des cellules hôtes et des procédés permettant de fabriquer ladite protéine ligand de P-sélectine. Des compositions pharmaceutiques contenant cette protéine et des procédés de traitement d'états inflammatoires caractérisés par des adhérences intercellulaires induites par la P-sélectine et la E-sélectine sont également décrites.

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