P-selectin ligands and related molecules and methods

Details P-selectin ligands and related molecules and methods P-selectin ligands and related molecules and methods

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 9/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224625

Disclosed herein are organic molecules to which are covalently bonded a sialyl- Lex determinant and a sulfated determinant, at least one of these determinants being positioned at a non-naturally occurring site on the molecule. Also disclosed are particular P-selectin ligands and P-selectin ligand-antibody fusions. These moecules, ligands, and fusion proteins find use in methods of reducing or protecting against inflammation and extravasation-dependent adverse reactions, such as organ damage and clotting (for example, associated with adult respiratory distress syndrome or ischemic myocardial injury).

Cette invention concerne des molécules organiques auxquelles sont liés par covalence un déterminant sialyl-Le?x¿ et un déterminant sulfaté, l'un au moins de ces déterminants se trouvant dans un site d'origine non naturelle de la molécule. Cette invention concerne également des ligands de P-sélectine particuliers ainsi que des fusions ligands de P-sélectine-anticorps. Ces molécules, ces ligands et ces protéines de fusion peuvent être utilisés afin de diminuer des réactions adverses liées à des inflammations et à des épanchements, ou encore afin d'assurer une protection contre ces dernières, comme, par exemple, les dommages subis par des organes et la coagulation (associés, par exemple, au syndrome de détresse respiratoire ou à des lésions myocardiques ischémiques chez l'adulte).

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