P-selectin translocation to vascular epithelial lumen by...

Details P-selectin translocation to vascular epithelial lumen by... P-selectin translocation to vascular epithelial lumen by...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/702 (2006.01) A61K 31/715 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 41/00 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2290563

The present invention relates to the use of P-selectin as a targeting agent in radiotherapies for vascular related disease. P-selectin is translocated to the lume of vascular endothelia as a result of radiation. Thus, P-selecting provides a target for receptor-mediated delivery of drugs, including anticancer drugs and drugs for the treatment of vascular disease. However, P- selectin also plays a role in the activation of certain inflammatory cells and, as such, plays a role in radiation-induced inflammation. By interfering with P-selectin induction of inflammation, it is possible to modulate inflammatory responses to radiation therapy.

L'invention concerne l'utilisation de P-sélectine comme agent de ciblage pour les radiothérapies de maladies à composante vasculaire. La P-sélectine est acheminée dans la lumière de l'endothélium vasculaire sous l'effet du rayonnement. Ainsi la P-sélectine forme une cible pour l'administration de médicaments via un récepteur, notamment pour des médicaments anticancéreux et des médicaments pour traiter les maladies vasculaires. Toutefois la P-sélectine joue également un rôle dans l'activation de certaines cellules inflammatoires et intervient donc dans l'inflammation induite par rayonnement. En interférant sur l'induction de l'inflammation par P-sélectine, il est possible de moduler les réactions inflammatoires à la radiothérapie.

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