P-(sulfonyl)aryl and heteroaryls

Details P-(sulfonyl)aryl and heteroaryls P-(sulfonyl)aryl and heteroaryls

C - Chemistry, Metallurgy

07

C

C07C 317/36 (2006.01) A61K 31/145 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/63 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07C 317/28 (2006.01) C07C 323/36 (2006.01) C07D 207/14 (2006.01) C07D 213/38 (2006.01) C07D 213/74 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2405832

This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. The claimed compounds have prostaglandin G/H synthase inhibitor activity and are suitable for the treatment of inflammatory diseases, such as myositis, synovitis, rheumatoid arthritis, osteoarthritis, gout, ankylosing spondylitis and bursitis, for the treatment of Alzheimer's disease or of an autoimmune disease such as systemic lupus erythematosus and type I diabetes.

Cette invention concerne des composés anti-inflammatoires et analgésiques, en particulier certains dérivés p-(sulfonyl)phényl amino, des compositions pharmaceutiques renfermant ces composés, des méthodes d'utilisation desdites compositions et des procédés de fabrication desdits composés. Ces composés, qui ont une activité inhibitrice de la prostaglandine G/H synthase, conviennent pour le traitement de maladies inflammatoires telles que la myosite, la synovite, la polyarthrite rhumatoïde, l'ostéarthrite, la goutte, la spondylite ankylosante et la bursite, ainsi que pour le traitement de la maladie d'Alzheimer ou d'une maladie autoimmune telle que le lupus erythémateux systémique et la diabète de type I.

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