C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/185 (2006.01) A61K 31/519 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07C 309/30 (2006.01) C07D 307/20 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2666537
The present disclosure relates to p-toluene sulfonic acid salt of 5-amino-3-(2'-O-acetyl-3'-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and to its use in treating conditions such as viral infections, tumors, and cancer. Also disclosed is a method of preparing the p-toluene sulfonic acid salt of 5-amino-3-(2'-O-acetyl-3'-deoxy-.beta.-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and methods for producing furanose compounds which are useful intermediates in the preparation of pharmaceutical compounds such as p-toluene sulfonic acid salt of 5-amino-3-(2'-O-acetyl-3'-deoxy-.beta.-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.
Cette invention se rapporte à un sel de l'acide p-toluène sulfonique de 5-amino-3-(2'-O-acétyl-3'-désoxy-bêta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidine-2-one et son utilisation dans le traitement de pathologies comme les infections virales, les tumeurs et le cancer. L'invention concerne également un procédé de préparation du sel de l'acide p-toluène sulfonique du 5-amino-3-(2'-O-acétyl-3'-désoxy-.beta.-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidine-2-one et des procédés de production de composés à base de furanose qui constituent d'utiles intermédiaires dan la préparation de composés pharmaceutiques en tant que sel de l'acide p-toluène sulfonique de 5-amino-3-(2'-O-acétyl-3'-désoxy-.beta.-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidine-2-one, et autres composés similaires.
Blatter Fritz
Haley Gregory J.
Kucera David
Rueden Erik J.
Viertelhaus Martin
Anadys Pharmaceuticals Inc.
Smart & Biggar
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